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KMID : 0043320180410111082
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Archives of Pharmacal Research
2018 Volume.41 No. 11 p.1082 ~ p.1091
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Chemical constituents of the roots of Codonopsis lanceolata
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Du Young-Eun
Lee Jin-Su
Kim Hye-Mi
Ahn Ji-Hye
Jung In-Ho
Ryu Jong-Hoon
Choi Jung-Hye
Jang Dae-Sik
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Abstract
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A new phenylpropanoid (1), a new alkaloid (11), and a new natural polyacetylene (17), together with nine phenolic compounds (2?10), five alkaloids (12?16), three polyacetylenes (18?20), three triterpenoidal saponins (21?23), one phenylethanoid glycoside (24), and three hexyl glycosides (25?27) with previous known structures, were isolated from the roots of Codonopsis lanceolata. All of the isolates 1?27 were evaluated for their inhibitory effects on LPS-induced nitric oxide (NO) production in RAW 264.7 macrophages and cell viability in A2780 human ovarian cancer cells. Among the isolates, lancemasides A and B have a significant inhibitory effect on the production of NO in RAW264.7 cells (IC50 values?
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KEYWORD
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Codonopsis lanceolate, Campanulaceae, Lancemasides, Nitric oxide, Ovarian cancer cells
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